Radiopharma Development | NorthStar Medical Radioisotopes, LLC

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data-natural-height="1700"></div> <div class="section-content "> <section class="h1_header_tall"> <div class="container"> <div class="header-inner"> <a href="https://www.northstarnm.com/development/" class="h1_breadcrumb_link md-blue">Development</a> <div class="title-divider ac-md-blue"></div> <h1 class="mb-5">Radiopharma<br><span>Development</span></h1> <div class="h_intro_box bg-dk-blue-gray p-4 mb-5"> <div class="h_intro_box_inner"> <p><strong>NorthStar Radiopharmaceutical Development Support</strong><br /> Radiopharmaceuticals are very different to traditional pharmaceutical products. Developing radiopharmaceuticals for imaging and therapeutic purposes requires specialized knowledge, skills and infrastructure. NorthStar is ideally positioned to help pharmaceutical companies develop molecules that will optimally bind with a range of radioisotopes, and to ensure the binding process is efficient, reliable and repeatable.</p> </div> </div> </div> </div> </section> <section class="r7_row_multicolumns py-normal " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column mr-auto"> <div class="p-5 bg-blue white"> <div class="row align-items-start "> <div class="col-12 "> <div class="copy mb-4 mb-md-0"> <h3 style="font-weight: 600; line-height: 1.4;">NorthStar has several development programs in place that demonstrate this capability.</h3> </div>  </div> </div> </div> </div> </div> </div> </section> </div> </section> <section class="section-bg " > <div class="parallax-container section-parallax" data-parallax="scroll" data-position="top" data-bleed="10" data-image-src="https://www.northstarnm.com/wp-content/uploads/2023/04/bg-blue-spheres-scaled.jpg" data-natural-width="1392" data-natural-height="2560"></div> <div class="section-content "> <section class="r7_row_multicolumns py-normal " > <div class="container"> <div class="row"> <div class="col-md-9 relative d-flex flex-column mr-auto"> <div class="p-5 bg- bg-capella"> <div class="row align-items-start "> <div class="col-md-5 pt-0 pt-md-5 text-left"> <div class="featured-img"> <a href="https://www.capellaimaging.net/" target="_blank"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/04/logo-capella.svg" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </a> </div> </div> <div class="col-md-7 "> <div class="copy mb-4 mb-md-0"> <p>FibroScint (Tc-99m F4A) is a fibrin-targeted, peptide compound labeled with the radioisotope technetium-99m (Tc-99m) for SPECT imaging of conditions such as Pulmonary Embolism (PE), Deep Vein Thrombosis (DVT) and Acute Coronary Syndrome (ACS). NorthStar licensed the global commercial rights to this product, and made a minority investment in Capella Imaging, in 2020. The licensing agreement called on NorthStar to support the development of the product, and NorthStar Nuclear Pharmacists and Radiochemists have led work to make the compound usable in a commercial radiopharmacy by making the formulation and binding process much faster and more reliable, and with a high yield. NorthStar is also working with Capella to develop an eIND such that initial clinical studies can start in the near future.</p> </div>  </div> </div> </div> </div> </div> </div> </section> <section class="r7_row_multicolumns py-normal-b " > <div class="container"> <div class="row"> <div class="col-md-9 relative d-flex flex-column ml-auto"> <div class="p-5 bg- bg-monopar"> <div class="row align-items-start "> <div class="col-12 mb-5"> <div class="featured-img"> <a href="https://www.monopartx.com/" target="_blank"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/04/logo-monopar.svg" class=" w-100 img-fluid mb-5 mb-lg-0" alt="" /> </a> </div> </div> <div class="col-12 "> <div class="copy mb-4 mb-md-0"> <p>NorthStar formed a 50:50 collaboration with Monopar Therapeutics in early 2020, with an initial vision to combine Monopar’s uPAR binding agent NMPR-101 with a therapeutic radioisotope such as Ac-225. Given that cells infected with COVID-19 expressed receptors with which MNPR-101 would bind strongly, these cells could be selectively destroyed by an alpha emitting radioisotope. NorthStar provided the expertise related to binding radioisotopes with pharmaceuticals as well as procuring and transporting the Radioisotopes. This work has led to two patents related to binding being published in 2022. Due to market and clinical trial dynamics, both companies agreed in early 2022 to also purse Oncology indications since uPAR is also expressed by multiple cancers. The program is expected to start Phase 0 imaging studies in a range of Cancer indications later this year, based on the strong results seen in images from multiple animal model cancers. Successful completion of the Phase 0 imaging studies during 2023 will provide a very compelling proof of concept since with Radiopharmaceuticals we know that “if you can see it, you can treat it”. Initial cancer target selection will occur once Phase 0 data is analyzed.</p> </div>  </div> </div> </div> </div> </div> </div> </section> <section class="r7_row_multicolumns py-normal-b " > <div class="container"> <div class="row"> <div class="col-md-9 relative d-flex flex-column mr-auto"> <div class="p-5 bg-white "> <div class="row align-items-start "> <div class="col-md-5 pt-0 pt-md-5 text-left"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/04/logo-inhibrx.png" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-7 "> <div class="copy mb-4 mb-md-0"> <p>NorthStar entered into an agreement with Inhibrx to select a range of Inhibrx designed single domain antibodies that would both bind well with cancer cell receptors and with both therapeutic and diagnostic radioisotopes. The first four candidates are in the process of being selected. NorthStar will focus on the radiochemistry, radiopharmacy, patient dose manufacture and logistics while Inhibrx will focus on pharmaceutical development and clinical trial work. Both companies envisage continuously assessing candidate compounds to develop a steady flow of potential Radiopharmaceuticals that could be of interest to Pharmaceutical Companies.</p> </div>  </div> </div> </div> </div> </div> </div> </section> </div> </section> <section class="section-bg " style="background-image: url(https://www.northstarnm.com/wp-content/uploads/2023/04/bg-blue-earth.jpg);" > <div class="section-content white"> <section class="r7_row_multicolumns " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column mr-auto"> <div class="row py-tall align-items-center "> <div class="col-md-6 "> <h2 class="title mb-4 "> Our <span>Mission</span> </h2> <div class="lead mb-5"> <p>PROVIDING PATIENTS GLOBAL ACCESS TO GAME-CHANGING RADIOPHARMACEUTICALS</p> </div>  </div> <div class="col-md-1 "> </div> <div class="col-md-5 "> <div class="copy mb-4 mb-md-0"> <p>NorthStar expects to add more agreements in the coming months and years. Companies interested in partnering with us should contact <strong>RPTinfo</strong><strong>@northstarnm.com</strong>.</p> </div>  </div> </div> </div> </div> </div> </section> </div> </section> </div> <footer class="py-5"> <div class="container"> <div class="row"> <div class="col-12 col-md-4 mb-4 mb-md-0 py-md-2"> <p class="footer-brand"><img src="https://www.northstarnm.com/wp-content/themes/northstar/img/logo-w.svg" alt="NorthStar Medical Radioisotopes, LLC" class="w-100 img-fluid" /></p> <div class="contact-box"> <p>1800 Gateway Boulevard<br /> Beloit, WI 53511<br /> <strong>Phone:</strong> <a href="tel:8444386659">(844) 438-6659</a><br /> <strong>Phone:</strong> <a href="tel:6083138000">(608) 313-8000</a></p> </div> </div> <div class="col-md-4 py-md-2 mb-4 mb-md-0"> <div class="menu-main-menu-container"><ul id="menu-main-menu-2" class="menu" itemscope itemtype="http://www.schema.org/SiteNavigationElement"><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-12125"><a href="https://www.northstarnm.com/radiopharmaceutical-therapy/">Radiopharmaceutical Therapy</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-12604"><a href="https://www.northstarnm.com/cdmo-cmo/">CDMO/CMO</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page current-page-ancestor current-menu-ancestor current-menu-parent current-page-parent current_page_parent current_page_ancestor menu-item-10982"><a href="https://www.northstarnm.com/development/">Development</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-10981"><a href="https://www.northstarnm.com/company/">Company</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-10980"><a href="https://www.northstarnm.com/careers/">Careers</a></li> <li class="searchlink menu-item menu-item-type-custom menu-item-object-custom menu-item-10984"><a href="#search"><i class="fas fa-search"></i> <span class="navhide">Search</span></a></li> </ul></div> </div> <div class="col-12 col-md-4 mb-4 mb-md-0 border-left px-md-4 py-md-2"> <div class="f-col-title"> HOW CAN WE HELP? </div> <div class="f-col-content"> <p>Questions about our company, products, supply solutions, careers or anything else?</p> </div> <div class="f-col-link"> <a href="https://www.northstarnm.com/company/contact-us/" target="" class="btn btn-wire">Contact Us</a> </div> <div class="inline-links"> <ul class="social-links"> <li><a href="https://www.linkedin.com/company/northstar-medical-radioisotopes-llc/" target="_blank" title=""><span class="social-text">LinkedIn</span><span class="fa-stack" style="vertical-align: top;"> <i class="fas fa-circle fa-stack-2x"></i> <i class="fab fa-linkedin-in fa-stack-1x fa-inverse"></i> </span></a></li> <li><a href="https://www.instagram.com/northstarmedicalradioisotopes/" target="_blank" title=""><span class="social-text">Instagram</span><span class="fa-stack" style="vertical-align: top;"> <i class="fas fa-circle fa-stack-2x"></i> <i class="fab fa-instagram fa-stack-1x fa-inverse"></i> </span></a></li> </ul> </div> </div> <div class="col-12 footer-copyright py-3 mb-5 white"> ©<script>var CurrentYear = new Date().getFullYear(); document.write(CurrentYear);</script> NMR. 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