Determination of Cyclic Citrullinated Peptide Antibodies on Quartz Crystal Microbalance Based Nanosensors

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Determination of Cyclic Citrullinated Peptide Antibodies on Quartz Crystal Microbalance Based Nanosensors</title> <meta name="description" content="Determination of Cyclic Citrullinated Peptide Antibodies on Quartz Crystal Microbalance Based Nanosensors"> <meta name="keywords" content="Anti-CCP, molecular imprinting, QCM nanosensor, rheumatoid arthritis."> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="Determination of Cyclic Citrullinated Peptide Antibodies on Quartz Crystal Microbalance Based Nanosensors"> <meta name="citation_author" content="Y. Saylan"> <meta name="citation_author" content="F. Yılmaz"> <meta name="citation_author" content="A. Denizli"> <meta name="citation_publication_date" content="2015/02/02"> <meta name="citation_journal_title" content="International Journal of Chemical and Molecular Engineering"> <meta name="citation_volume" content="9"> <meta name="citation_issue" content="3"> <meta name="citation_firstpage" content="416"> <meta name="citation_lastpage" content="419"> <meta name="citation_pdf_url" content="https://publications.waset.org/10000694/pdf"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value=""> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 33093</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Determination of Cyclic Citrullinated Peptide Antibodies on Quartz Crystal Microbalance Based Nanosensors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Y.%20Saylan">Y. Saylan</a>, <a href="https://publications.waset.org/search?q=F.%20Y%C4%B1lmaz"> F. Yılmaz</a>, <a href="https://publications.waset.org/search?q=A.%20Denizli"> A. Denizli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>In this study, we have focused our attention on combining of molecular imprinting into nanofilms and QCM nanosensor approaches and producing QCM nanosensor for anti- CCP, chosen as model protein, using anti-CCP imprinted nanofilms. The nonimprinted nanosensor was also prepared to evaluate the selectivity of the imprinted nanosensor. Anti-CCP imprinted QCM nanosensor was tested for real time detection of anti-CCP from aqueous solution. The kinetic and affinity studies were determined by using anti-CCP solutions with different concentrations. The responses related with mass shifts (%m) and frequency shifts (%f) were used to evaluate adsorption properties. To show the selectivity of the anti-CCP imprinted QCM nanosensor, competitive adsorption of anti-CCP and IgM was investigated. The results indicate that anti- CCP imprinted QCM nanosensor has higher adsorption capabilities for anti-CCP than for IgM, due to selective cavities in the polymer structure.</p> <iframe src="https://publications.waset.org/10000694.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Anti-CCP" title="Anti-CCP">Anti-CCP</a>, <a href="https://publications.waset.org/search?q=molecular%20imprinting" title=" molecular imprinting"> molecular imprinting</a>, <a href="https://publications.waset.org/search?q=QCM%20nanosensor" title=" QCM nanosensor"> QCM nanosensor</a>, <a href="https://publications.waset.org/search?q=rheumatoid%20arthritis." title=" rheumatoid arthritis."> rheumatoid arthritis.</a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.1099620" target="_blank">doi.org/10.5281/zenodo.1099620</a> </p> <a href="https://publications.waset.org/10000694/determination-of-cyclic-citrullinated-peptide-antibodies-on-quartz-crystal-microbalance-based-nanosensors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000694/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000694/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10000694/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10000694/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10000694/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10000694/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10000694/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10000694/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10000694/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10000694/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10000694.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2260</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] E. Yılmaz, L. Uzun, A.Y. Rad, U. Kalyoncu, S. Ünal, A. Denizli, “Specific adsorption of the autoantibodies from rheumatoid arthritis patient plasma using histidine-containing affinity beads,” J. Biomat. Sci- Polym E, vol. 19, pp. 875-892, 2008. <br>[2] M.A. Van Boekel, E.R. Vossenaar, F.H. van den Hoogen, W.J. van Venroo, “Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value,” Arthritis Res, vol. 4, pp. 87-93, 2002. <br>[3] F. J. Diaz, A. Rojas-Villarraga, J. C. Salazar, A. Iglesias-Gamarra, R. D. Mantilla, J.M. Anaya, “Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis,” Joint Bone Spine, vol. 78, pp. 175-178, 2011. <br>[4] J.L. Caro-Oleas, A. Fernández-Suárez, S. Reneses Cesteros, C. Porrino, A. Núñez-Roldán, I. Wichmann Schlipf, “Evaluation of third generation anti-CCP antibodies in the diagnosis of rheumatoid arthritis from undifferentiated polyarthritis after 4 years of follow-up,” Clin Exp Rheumatol, vol.26, pp. 461-463, 2008. <br>[5] N. Bereli, Y. Saylan, L. Uzun, R. Say, A. Denizli, “L-Histidine imprinted supermacroporous cryogels for protein recognition,” Sep Purif Technol, vol. 82, pp. 28-35, 2011. <br>[6] Y. Saylan, R. Üzek, L. Uzun, A. Denizli, “Surface imprinting approach for preparing specific adsorbent for IgG separation,” J. Biomat. Sci- Polym E, vol. 25, pp. 881-894, 2014. <br>[7] Y. Lv, T. Tan, F. Svec, “Molecular imprinting of proteins in polymers attached to the surface of nanomaterials for selective recognition of biomacromolecules,” Biotechnol. Adv, vol. 31, pp. 1172-1186, 2013. <br>[8] G. Sener, E. Özgur, E. Yılmaz, L. Uzun, R. Say, A. Denizli, “Quartz crystal microbalance based nanosensor for lysozyme detection with lysozyme imprinted nanoparticles,” Biosens Bioelectron, vol. 26, pp. 815-821, 2010. <br>[9] E. Yilmaz, D. Majidi, E. Ozgur, A. Denizli, “Whole cell imprinting based Escherichia coli sensors: A study for SPR and QCM,” Sensors Actuator, vol. 209, pp. 714-721, 2015. <br>[10] A. H. Wu, M. J. Syu, “Synthesis of bilirubin imprinted polymer thin film for the continuous detection of bilirubin in an MIP/QCM/FIA system,” Biosens Bioelectron, vol. 21, pp. 2345-2353, 2006. <br>[11] S. Emir Diltemiz, D. Hür, A. Ersöz, A. Denizli, R. Say, “Designing of MIP based QCM sensor having thymine recognition sites based on biomimicking DNA approach,” Biosensor Bioelectron, vol. 25 pp. 599- 603, 2009. <br>[12] K. Feng, J. Li, J. H.Jiang, G. L. Shen, R. Q. Yu, “QCM detection of DNA targets with single-base mutation based on DNA ligase reaction and biocatalyzed deposition amplification,” Biosens Bioelectron, vol. 22 pp. 1651-1657, 2007. <br>[13] A. Ersöz, S. Emir Diltemiz , A. Atılır Özcan, A. Denizli, R. Say, “8- OHdG sensing with MIP based solid phase extraction and QCM technique,” Sensors Actuator, vol. 137, pp. 7-11, 2009. <br>[14] I. Mannelli, M. Minunni, S. Tombelli, M. Mascini, “Quartz crystal microbalance (QCM) affinity biosensor for genetically modified organisms (GMOs) detection,” Biosensor Bioelectron, vol. 18 pp. 129- 140, 2003. </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>

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Determination of Cyclic Citrullinated Peptide Antibodies on Quartz Crystal Microbalance Based Nanosensors